• Inflammations lead to the perturbation of aromatase

  2024-04-30

  

  Inflammations lead to the perturbation of aromatase enzyme [112], which normally is responsible for a broad array of critical functions. Chemotherapy targets this enzyme, so this treatment option is never side-effect-free and not fully-effective. Therefore, the mankind should be careful so as not to

• Despite these conflicting data about COX ER correlations a l

  2024-04-30

  

  Despite these conflicting data about COX-2/ER correlations, a large body of evidence supports that elevated COX-2 expression in breast cancer is a constant feature of high stage disease and a predictor of worse outcome. Upregulation of COX-2 protein has been identified in approximately 40% of cases

• 5104 br Conclusions In summary aromatase

  2024-04-30

  

  Conclusions In summary, aromatase mRNA expression in the 5104 of A. leptorhynchus shows a similar distribution pattern as seen in other teleosts with expression detected in the forebrain and the pituitary gland. The lack of aromatase mRNA expression in the midbrain and hindbrain of A. leptorhync

• br Methodology br Antibiotics in lakes br

  2024-04-30

  

  Methodology Antibiotics in lakes Antibiotic resistance genes in lakes Perspectives of study on Voriconazole mg and ARGs in lakes Conclusion This paper systematically reviewed the distribution of antibiotics and ARGs in global lakes. A total of 57 antibiotics reported at least once in

• br Conflicts of interest br Funding

  2024-04-29

  

  Conflicts of interest Funding Introduction Brassicaceae is an economically important family of plants containing rapeseed, cabbage, broccoli, brussels, radish and mustard. Among them rapeseed plays a crucial role, because of its application in food and also in fuel industry. According to th

• Liver plays a pivotal role in metabolism of xenobiotic compo

  2024-04-29

  

  Liver plays a pivotal role in metabolism of xenobiotic compounds, such as environmental contaminants and drugs. Some of these compounds generate hepatic damage and impair its function. It was well-known that 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) could induce pathological changes in mouse and ra

• br Conflict of Interest br Transparency Document br

  2024-04-29

  

  Conflict of Interest Transparency Document Introduction Mitoxantrone (MXT) is an androstenedione chemotherapeutic agent that is used to treat acute nonlymphocytic leukemia, acute lymphoblastic leukemia, prostate cancer, metastatic breast cancer, and non-Hodgkin’s lymphoma [13], [14]. It is

• The difference in the mean values of serum ADA

  2024-04-29

  

  The difference in the mean values of serum ADA in sputum positive PTB and controls was found to be highly significant (P Discussion Tuberculosis is a major health problem in India, and out of all its forms PTB is the commonest. A definite diagnosis of PTB can be made with the presence of nmda rece

• br Acknowledgements br Introduction Autoantibodies directed

  2024-04-29

  

  Acknowledgements Introduction Autoantibodies directed at neurotransmitter receptors and ion channels are pathogenic and/or biomarkers in several autoimmune neurological diseases [1]. For example, autoantibodies directed against voltage-gated potassium channels, the P/Q-type (α1A) voltage-gated

• br Conclusion There have been multiple clinical trials and

  2024-04-29

  

  Conclusion There have been multiple clinical trials and pre-clinical studies that have tested the utility of 5ARIs in treating prostate disease, as summarized in Fig. 1. Inhibiting androgen action through the use of finasteride and dutasteride has been established as a valuable resource for physi

• The presence of different LO splice variants was first demon

  2024-04-29

  

  The presence of different 5-LO splice variants was first demonstrated in human Protease Inhibitor Cocktail (EDTA-Free, 100X in DMSO) tumour cells and in dimethyl sulfoxide-differentiated HL-60 cells [40] and a correlation between the 5-LO splicing pattern and the malignancy of the brain tumours was

• br Dual role of autophagy

  2024-04-29

  

  Dual role of autophagy in human diseases Emerging evidence suggests that autophagy serves as a double-edged sword in several human diseases, such as CNS diseases (Rubinsztein et al., 2015), arteriosclerosis (Schrijvers et al., 2011) and cancer (Ozpolat and Benbrook, 2015). Likewise, currently the

• If the lack of specificity and

  2024-04-29

  

  If the lack of specificity and the high pleiotropy may represent a problem in view of the potential chemotherapeutic features of autophagy-inducing agents, it SGC 0946 may switch into an advantage in the case of chemopreventive strategies. In fact, as non-pharmacologic interventions such as limited

• br Regulation of V ATPase

  2024-04-29

  

  Regulation of V-ATPase assembly in response to changes in amino s7694 receptor levels A central regulator of cell growth and metabolism is mTORC1 [38]. mTORC1 integrates signals from nutrient availability and growth factor receptors to control such processes as protein and lipid synthesis and au

• br Conflicts of interest br

  2024-04-29

  

  Conflicts of interest Introduction Phosphatidic Tenovin-1 phosphatase (PAP) enzymes are responsible for catalyzing the reaction that dephosphorylates phosphatidic acid (PA), which in turn produces diacylglycerol (DAG) and a phosphate group during phospholipid regulation (Fig. 1A) [1]. Subsequ

15511 records 155/1035 page Previous Next First page 上5页 151152153154155 下5页 Last page