• The zebrafish Danio rerio is a popular model organism for

  2025-02-10

  

  The zebrafish (Danio rerio) is a popular model organism for virtually any biological function of vertebrates, and has, therefore, received a wide distribution in particular in developmental biology and toxicology (Strähle et al., 2012). With respect to AChE, the zebrafish has, e.g., been identified

• We found that several anticancer drugs inhibit HT

  2025-02-10

  

  We found that several anticancer drugs inhibit 5-HT3 Pituitary hormone analog current in vitro. Several studies have suggested that 5-HT3 receptor antagonists have anti-mitogenic and apoptotic effects on colorectal and breast cancer cell lines (Ataee et al., 2010, Hejazi et al., 2015). Irinotecan i

• Drug resistance development often involves structurally un r

  2025-02-10

  

  Drug resistance development often involves structurally un-related drugs and, specifically both conventional and targeted agents. IGROV-1/Pt1 diacerein mg are characterized by resistance to cisplatin and reduced sensitivity to inhibitors of EGF-R and MEK, the up-stream activator of ERK1/2, associat

• It has been reported that Daxx an interacting partner of

  2025-02-10

  

  It has been reported that Daxx, an interacting partner of MCRS2/MSP58, promotes ASK1 activation following direct interaction with ASK1 [10], [11]. However, it has not been determined whether MCRS2 is involved in ASK1 signalling. In this study, we identified the direct interaction between MCRS2 and A

• Bioavailability has been defined as the amount of a drug

  2025-02-10

  

  Bioavailability has been defined as the amount of a drug given by any route, other than intravenously, that reaches general circulation and is available at the site of action [86]. The low bioavailability observed with the initial intravaginal devices (16%) was attributed to the melting point of the

• Mitochondria are key organelles involved in the mechanism of

  2025-02-10

  

  Mitochondria are key organelles involved in the mechanism of apoptosis (Xiong et al., 2014), and loss of ΔΨm is an important marker associated with mitochondrial dysfunction and cell death. We found that Mino induced ΔΨm impairment and nuclear fragmentation in Jurkat PHA-767491 in a concentration-de

• potassium hydrochloride sale AP activity is increased by MAP

  2025-02-10

  

  AP-1 activity is increased by MAP kinase stimulation in different cell types (Whitmarsh and Davis, 1996), while MKP-1, the enzyme that catalyzes the dephosphorylation and inactivation of MAP kinases in the nucleus, inhibits AP-1 (Rössler et al., 2008, Rössler and Thiel, 2009, Mayer et al., 2011, Thi

• Psychiatric medication br HMGB proteins and chromatin struct

  2025-02-08

  

  HMGB proteins and chromatin structure The multifaceted roles played by HMGB (formerly called HMG-1 and -2) proteins in modulating chromatin structure, gene transcriptional activity and cellular phenotype have been covered in a number of recent reviews and readers are referred to these for in-dept

• Most clinically approved antiangiogenic drugs are

  2025-02-08

  

  Most clinically approved antiangiogenic drugs are aimed at blocking the action of vascular endothelial growth factor, or VEGF, which is accepted to be the most important tumor-derived angiogenic factor, stimulating proliferation and migration of endothelial cells, as well as branching of vessels (Fe

• The proinflammatory cytokines and chemokines including IL TN

  2025-02-08

  

  The proinflammatory cytokines and chemokines, including IL-1β, TNF-α and MCP-1, mediate acute and chronic inflammation and play a role in the development of hypertension [2, [51], [52], [53]], cardiovascular diseases [4, 54] and renal injury [55, 56] in animal models and humans. Concerning the possi

• Here we found that AMPK directly phosphorylates EZH

  2025-02-08

  

  Here we found that AMPK directly phosphorylates EZH2 at Thr311 to disrupt its interaction with SUZ12 and to inhibit PRC2 enzymatic activity, which is supported by the increased expression of PRC2-repressed genes. Furthermore, the T311E-EZH2 mutant that mimics AMPK-mediated phosphorylation status sup

• Circular dichroism CD provides useful

  2025-02-08

  

  Circular dichroism (CD) provides useful information about protein structure, the extent and rate of structural changes and ligand binding. CD is a form of light JNK-IN-8 chemical spectroscopy that measures differences in the absorbance of right- and left-circularly polarized light (rather than the

• ppar pathway In view of the ubiquitous

  2025-02-08

  

  In view of the ubiquitous distribution of the arachidonate 12S-lipoxygenase isoforms and the variety of cellular reactions influenced by the resulting arachidonate metabolites, these products widely play important roles in many biological systems. The development of new type-specific inhibitors of t

• Chemotherapeutic agent These findings suggest that eventuall

  2025-02-08

  

  These findings suggest that eventually more than one 12/15-lipoxygenase isoform may play a role in human atherosclerosis. Humans have two 12-lipoxygenases and two 15-lipoxygenases which show different expression patterns, substrate specificities and stereo-selective metabolism [1]. However, in Chemo

• br Materials and methods br Results br

  2025-02-08

  

  Materials and methods Results Discussion Knowledge of the molecular basis of an inherited genetic disease is crucial for understanding the disease pathology and, ultimately, for therapeutic design. Several recent reports have stressed the need for physical characterization of disease-associ

15546 records 16/1037 page Previous Next First page 上5页 1617181920 下5页 Last page