• Introduction Although G protein coupled receptor

  2022-02-26

  

  Introduction Although G-protein-coupled receptor 55 (GPR55) was considered a cannabinoid receptor, it differs phylogenetically from cannabinoid type 1 (CB1) and type 2 (CB2) receptors as it lacks the classic cannabinoid-binding pocket (Baker et al., 2006). GPR55 is sensitive to an array of cannabin

• br GPR a G protein coupled

  2022-02-26

  

  GPR35, a G protein-coupled receptor (GPCR), was discovered and classified as an orphan GPCR in 1998 and deorphanized in 2006 by the discovery of kynurenic Quinacrine hydrochloride hydrate as the endogenous agonist. Since its discovery, limited references on the GPR35 receptor have appeared, due i

• Thyroid hormone triiodothyronine T and its

  2022-02-26

  

  Thyroid hormone 3,5,3′-triiodothyronine (T3) and its precursor, thyroxine (T4), are iodinated compounds, which are known to regulate the expression of genes involved in various biological processes, such as development, growth and metabolic control. The iodothyronine deiodinase types I, II and III (

• The role of the ER EK variant

  2022-02-26

  

  The role of the ER22/23EK variant which is associated with relative resistance to GC, as shown by a reduction of transactivating capacity in vitro and less suppression of Tobramycin levels after 1mg DST in vivo. Relative GC resistance associated with the ER22/23EK polymorphism might protect from th

• Extending time action is another strategy

  2022-02-26

  

  Extending time action is another strategy to increase in vivo efficacy. Twice daily administration of the unacylated analogs herein caused greater body weight loss in DIO mice than the equivalent dose administered as a single daily injection, suggesting that protracted time action should yield more

• In Gallus gallus four FGFRs

  2022-02-26

  

  In Gallus gallus, four FGFRs (FGFR1-4) have been identified, along with 13 FGFs (FGF1–4, 8–10, 12, 13, 16, 18–20) (Thisse and Thisse, 2005). FGFRs are tyrosine kinase receptors that contain an extracellular ligand binding domain, a transmembrane domain and an intracellular tyrosine kinase domain. Th

• To evaluate the role of increased

  2022-02-26

  

  To evaluate the role of increased FPPS expression in paclitaxel-treated cells, we investigated the effects of FPPS on Chaetocin progression. DNA content analysis showed that the number of cells accumulating in the G/M phase increased in a dose-dependent manner in paclitaxel-treated cells (A and B),

• Overall we partially confirmed our predictions and when comp

  2022-02-26

  

  Overall, we partially confirmed our predictions, and, when compared to the other existing dataset exploring the interaction among CRFR1, FAAH, and anxiety, our data are somewhat confirmatory. Demers and colleagues (Demers et al., 2016) found one (protective) CRFR1 minor allele (rs110402) and the (le

• Sperm exocytosis or acrosome reaction

  2022-02-26

  

  Sperm exocytosis or acrosome reaction (AR) is a regulated secretion with special characteristics essential for fertilization. The AR relies on the same highly conserved molecules that drive intracellular membrane fusion and exocytosis in all other THZ1 Hydrochloride (see [59] for a recent review).

• In a preliminary communication we showed that AT and

  2022-02-26

  

  In a preliminary communication, we showed that AT and ETB receptors colocalize and coimmunoprecipitate in renal proximal tubule cells, and stimulation of the AT receptor increases ETB receptor expression in Wistar-Kyoto (WKY) rats [abstract; Zeng C,, 26:80A, 2003]. We hypothesize that the ETB recept

• Thus far it is reported that the histone

  2022-02-26

  

  Thus far, it is reported that the histone methyltransferase activity of SUV39H1 is regulated through some posttranslational modifications. For example, deacetylation of SUV39H1 at Lys-266 by SIRT1 deacetylase increases SUV39H1 activity [31], and methylation of SUV39H1 at Lys-105 and Lys-123 by SET7

• 58 5 Lieber have discussed alcohol outside

  2022-02-25

  

  Lieber (2000), have discussed alcohol outside the context of hepatitis C infection exerts specific pathologic effects on the liver. Liver biopsies in patients with hepatitis C who drink alcohol are generally consistent with hepatitis C alone, with portal-based pathology, rather than alcoholic injury

• br Autophagy and HBV induced

  2022-02-25

  

  Autophagy and HBV-induced HCC Researchers have demonstrated downregulation of autophagy in HBV transgenic liver tumors of mouse models and in human HBV-induced HCC specimens. Kotsafti and his colleagues declared that the expression level of BECN1 mRNA in HCC specimens was considerably lower than

• There is evidence for an

  2022-02-25

  

  There is evidence for an adverse sympatho-stimulatory effect in the medulla oblongata mediated by the α1/β1 isoform, implying a possible benefit of selective α2/β1 activation [19]. While the stimulator BAY 41–2272 increases NO-sensitivity of both isoforms [20], a prevalence of the α1/β1 isoform comp

• Stimulation of GC A by CNP was further corroborated

  2022-02-25

  

  Stimulation of GC-A by CNP was further corroborated by using a cGMP enzyme immunoassay. We could show that CNP significantly stimulated cGMP synthesis in the GC-A reporter cell line. CNP stimulation resulted in similar maximal cGMP levels compared to stimulation by ANP and BNP. Therefore, by lumine

15511 records 460/1035 page Previous Next First page 上5页 456457458459460 下5页 Last page