• Studies of nuclear transplantation of diploid imprint free P

  2019-08-22

  

  Studies of nuclear transplantation of diploid imprint-free PGCs have shown that the reconstituted oocytes developed to day 9.5 of gestation, with severely retarded embryos and abnormal placentae (Kato et al., 1999). We also reported that MII oocyte injection of imprint-free phESCs without imprinted

• Our study revealed elevated basal Akt phosphorylation in

  2019-08-22

  

  Our study revealed elevated basal Akt phosphorylation in diet-induced obesity, the effect of which was reversed by ETAKO. Activation of Akt promotes cardiac hypertrophy via a number of cellular mechanisms including activation of its downstream targets such as mTOR and GSK3β [45, 46]. Short-term acti

• br The classical ubiquitination pathway Ubiquitination is

  2019-08-22

  

  The classical ubiquitination pathway Ubiquitination is an enzymatic process that involves the addition of an ubiquitin protein to a substrate that usually becomes inactivated followed by degradation in the proteasome; however, several other functions have also been described. For the discovery of

• br Results br Discussion The importance of mitochondria for

  2019-08-22

  

  Results Discussion The importance of mitochondria for the initiation and progression of tumorigenesis is now emerging. It is evident that, despite the well-known Warburg effect, tumors have active mitochondrial bioenergetic metabolism (Marin-Valencia et al., 2012, Hensley et al., 2016). Disrup

• Many filarial species harbor an endosymbiotic bacterium of

  2019-08-22

  

  Many filarial species harbor an endosymbiotic bacterium of the genus Wolbachia. A recent investigation of Wolbachia distribution in 35 filarial species including 28 species and 7 genera and/or subgenera have shown that 37% of them harbor Wolbachia (Ferri et al., 2011). In filarial nematodes, Wolbach

• Several highly potent CysLT receptor antagonists with large

  2019-08-22

  

  Several highly potent CysLT1 receptor antagonists with large structural nisin have been developed. Beyond antagonists with structures analogous to cysteinyl leukotrienes, other subclasses comprise: (a) hydroxyacetophenones, (b) indoles and indazoles, (c) quinolines, benzothiazoles, and thiazoles. O

• Finally the identification of predictive biomarkers of respo

  2019-08-22

  

  Finally, the identification of predictive biomarkers of response will also allow the more recently discovered CDK inhibitors to be explored in particular genetically-defined contexts, for example by building on recent observations that KRAS mutant tumors are highly sensitive to CDK1 inhibition, and

• br Effects of estradiol outside the

  2019-08-21

  

  Effects of estradiol outside the nucleus are often mediated by classical estrogen receptors Today, it is widely accepted that steroid hormones can signal in ways that do not rely on receptors acting in the nucleus, including activation of receptors localized to the cellular membrane. Rapid effect

• cAMP mediated signaling pathways are important for maintaini

  2019-08-21

  

  cAMP-mediated signaling pathways are important for maintaining metabolic homeostasis, and the effects of the glucagon/catecholamine–cAMP–PKA axis on energy balance have been well documented [20]. For example, herpes simplex virus 1 of the PKA 2β regulatory subunit (RIIβ) in mice leads to increased

• Introduction CYP is a superfamily of heme

  2019-08-21

  

  Introduction CYP450 is a superfamily of heme-containing monooxygenases, many of which are expressed in the liver, and they are significant phase-I 5959 in drug metabolism and detoxification. There are three subfamilies (CYP1, CYP2 and CYP3) that are mainly involved in the metabolism of drugs in bot

• TRAF and TRAF were initially identified as

  2019-08-21

  

  TRAF1 and TRAF2 were initially identified as tumor necrosis factor receptor 2 (TNRF2)-associated components, TRAF4 was overexpressed in breast carcinoma cells, whereas TRAF3, TRAF5 and TRAF6 were discovered by their interaction with specific domains in the cytoplasmic tails of trans-membrane recepto

• HCV has evolved mechanisms to

  2019-08-21

  

  HCV has evolved mechanisms to evade humoral immune responses including high functional flexibility and variability of immunogenic portions of its envelope proteins. The highest sequence variability occurs in the first 27 Diclofenac Sodium of the N-terminus of E2, which is referred to as the hyperva

• br Discussion The biochemical separation of exonuclease acti

  2019-08-21

  

  Discussion The biochemical separation of exonuclease activity from DNA-PK dependent endonuclease activity reported in this manuscript is consistent with genetic separation of Artemis enzymatic activity. Mutations in the protein which result in disruption of endonuclease activity have no effect on

• Oxamic acid A range of inhibitors were therefore synthesized

  2019-08-21

  

  A range of inhibitors were therefore synthesized containing either carboxylic Oxamic acid or ester functionality at the ‘tail’ group as well as variations in the ‘head.’ These were assayed in vitro using the DCIP assay for binding affinity against and human DHODH at 50μM, respectively (). Analysis

• Calcium dependence of CaM target interaction

  2019-08-21

  

  Calcium dependence of CaM/target interaction was analyzed using a titration matrix in which both Ca2+ and CaM concentrations were changed. This gave us access to different parameters characterizing the interaction and namely to the number of bound Ca2+ required for the interaction to occur. Our app

15511 records 968/1035 page Previous Next First page 上5页 966967968969970 下5页 Last page