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br Conclusion br Conflict of interest statement br Authors c
2019-05-27
Conclusion Conflict of interest statement Authors\' contribution Introduction There are two classes of bisphosphonates that differ with regard to structure and mechanism of action [1]. The first one includes pyrophosphate-resembling bisphosphonates, such as clodronate and etidronate, whi
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br Epigenetic regulation of genes involved in
2019-05-27
Epigenetic regulation of genes involved in hepatic lipid metabolism by S1P and SHP The signaling cascade of CBA > S1PR2 > SphK2 > S1P > HDAC1/2 > increased hepatic gene expression can differentially up-regulate blocks of genes involved in the hepatic metabolism of sterols and lipids (Fig. 3, Tabl
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carboxypeptidase a Confluye aqu en su literalidad en su capa
2019-05-27
Confluye aquí, en su literalidad, en su capacidad para evocar cierta “representación pura y simple de lo real”, esa retórica del cuerpo carboxypeptidase a la que hice referencia más arriba. “Cuerpo-texto que destruye el cuerpo-carne pero se monta en él para transformarlo, para sustituirlo”, en la Hi
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ache inhibitor Podr a pensarse pues que don Melchor
2019-05-27
Podría pensarse, pues, que don Melchor Carlos Inca estaba tan sólo construyendo el conveniente andamiaje discursivo y argumentativo que presentar ante el virrey condicionando una resolución favorable ache inhibitor sus intereses. Pero entraría en juego aquí una segunda fuente a nuestra disposición,
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Esta institucionalizaci n penetr en la sociedad por lo
2019-05-27
Esta institucionalización penetró en la sociedad, por lo que sus integrantes fueron apartándose de las prácticas políticas que pudiesen identificarlos como comunistas. En la etapa posdemocrática, el uso de palabras como filocomunistas o pro-comunistas, convivió con la instauración de los gobiernos e
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Premature deaths of women have profound
2019-05-27
Premature deaths of women have profound effects on families, societies, and economies, regardless of the age at which they occur and whatever the cause, including an—often preventable—NCD or injury later in life. Families, especially if female-headed, are driven into poverty through catastrophic hea
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ON-01910 Non communicable disease behavioural risk factors s
2019-05-27
Non-communicable disease behavioural risk factors such as tobacco smoking, heavy alcohol consumption, physical inactivity, and unhealthy eating are socially patterned in high-income countries, with individuals of low socioeconomic status generally experiencing a higher burden of risk factors. Howev
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br In the past year migration to Europe
2019-05-27
In the past year, migration to Europe from Africa and the Middle East has reached unprecedented levels. In 2016, 181 405 migrants reached the shores of Italy and more than 5000 died trying to reach the southern coasts of Europe. Many migrants seek to escape war, poverty, persecution, or ill treatm
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br Introduction Since Reekers and
2019-05-27
Introduction Since Reekers and Bolia introduced subintimal angioplasty, the trans-subintimal route has become the preferred technique to advance the guidewire through a totally occluded and often heavily calcified lesion, especially in the aortoiliac segment. The technical failure was seen in 20–
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The STAR VT trial is a randomized trial examining the
2019-05-27
The STAR-VT trial is a randomized trial examining the role of ablation in patient with an indication for ICD implantation [97]. The inclusion criteria targeting 562 patients with secondary prevention indications as well as primary prevention patients with inducible VT, where nonischemic cardiomyopat
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br Future potential cardiac examinations for long
2019-05-27
Future potential cardiac examinations for long-duration spaceflights Currently available treatments for emergency cases in spaceflight Astronaut Crew Medical Officers (CMO) aboard the ISS receive 40–70h of medical training, including CPR training, within 18 months preceding their mission (Fig.
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Otamixaban Involvement of the ventricular myocardium can
2019-05-27
Involvement of the ventricular myocardium can lead to delayed conduction or anatomical obstacles that are labile to ventricular tachyarrhythmia. Arrhythmias are independently predictive of sudden cardiac death (SCD) [9]. SCD is common in patients with cardiac AL amyloidosis, and prophylactic implant
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br Do we need complete isolation of all PVs
2019-05-27
Do we need complete isolation of all PVs in every patient? Circumferential PVI results in satisfactory outcomes for ablation of paroxysmal AF, and electrical isolation of all PVs is currently a standard approach to the treatment of AF, as recommended by the expert consensus statement [6]. Complet
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br Discussion SIS is a morphological characteristic of the b
2019-05-24
Discussion SIS is a morphological characteristic of the basal interventricular septum that protrudes into the LV cavity. This cardiac malformation has generally been considered a natural part of aging without pathophysiological or clinical significance [5,6]. However, several studies demonstrated
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Commission on Global Surgery s vision is
2019-05-24
Commission on Global Surgery\'s vision is “universal access to safe, affordable surgical and anaesthesia care when needed”. 5 billion people, largely the poor, marginalised, and rural, face impossible hurdles and for all practical purposes are excluded from what is often life-saving or disability-av
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